Download Alzheimer's disease and related disorders annual, 2002 by Jeffrey L Cummings, Serge Gauthier PDF

By Jeffrey L Cummings, Serge Gauthier

Given the advance of latest healing suggestions and items, Serge Gauthier and Jeffrey Cummings have compiled a listing of latest issues so that it will be of curiosity essentially to neurologists concentrating on Alzheimer's illness, and in addition to psychiatrists and geriatricians. The individuals, all revered of their subspecialties, have written up to date, comprehensively referenced chapters which should supply suggestions in addition to stimulate dialogue on the place present therapy is heading.

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Hensley K, Aksenova M, Carney JM et al. Amyloid beta-peptide spin trapping. I: Peptide enzyme toxicity is related to free radical spin trap reactivity. Neuroreport 1995; 6:489–492. 96. Hensley K, Butterfield DA, Mattson M et al. A model for beta-amyloid aggregation and neurotoxicity based on the free radical generating capacity of the peptide: implications of ‘molecular shrapnel’ for Alzheimer’s disease. Proc West Pharmacol Soc 1995; 38:113–120. 97. Chen Y, McPhie DL, Hirschberg J, Neve RL. The amyloid precursor protein-binding protein APP-BP1 drives the cell cycle through the SM checkpoint and causes apoptosis in neurons.

101. Shearman MS, Beher D, Clarke EE et al. L-685,458, an aspartyl protease transition state mimic, is a potent inhibitor of amyloid betaprotein precursor gammasecretase activity. Biochemistry 2000; 39:8698–8704. Alzheimers CH02 17/6/02 2:36 pm Page 37 References 102. Capsoni S, Ugolini G, Comparini A et al. Alzheimer-like neurodegeneration in aged antinerve growth factor transgenic mice. Proc Natl Acad Sci USA 2000; 97: 6826–6831. 103. Henriksson BG, Soderstrom S, Gower AJ et al. Hippocampal nerve growth factor levels are related to spatial learning ability in aged rats.

Expression of apoptosis related proteins in brains of patients with Alzheimer’s disease. Neurosci Lett 2001; 303:79–82. Alzheimers CH02 17/6/02 2:36 pm Page 33 References 30. Engidawork E, Gulesserian T, Yoo BC et al. Alteration of caspases and apoptosis-related proteins in brains of patients with Alzheimer’s disease. Biochem Biophys Res Commun 2001; 281:84–93. 31. Rohn TT, Head E, Nesse WH et al. Activation of caspase-8 in the Alzheimer’s disease brain. Neurobiol Dis 2001; 8:1006–1016. 32. Rohn TT, Head E, Su JH et al.

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